abstract：:Transdermal drug delivery is an emerging field in the pharmaceutical remit compared with conventional methods (oral and parenteral). Microneedle (MN)-based devices have gained significant interest as a strategy to overcome the skin's formidable barrier: the stratum corneum. This approach provides a less invasive, more...

journal_title：AAPS PharmSciTech

authors： Ali R,Mehta P,Arshad MS,Kucuk I,Chang MW,Ahmad Z

更新日期：2019-12-05 00:00:00

abstract：:As a synthetic clay material, laponite RDS (LR) was investigated as an effective drug carrier as a result of the special nanodisk structure together with the negative-charged surface to achieve enhanced cellular uptake and targeted delivery. In this research work, the synthesized oligomeric hyaluronic acid-aminophenyl...

journal_title：AAPS PharmSciTech

authors： Yang Y,Li J,Chen F,Qiao S,Li Y,Pan W

更新日期：2019-11-20 00:00:00

abstract：:This work presents a new user-friendly lyophilization simulation and process optimization tool, freely available under the name LyoPRONTO. This tool comprises freezing and primary drying calculators, a design-space generator, and a primary drying optimizer. The freezing calculator performs 0D lumped capacitance modeli...

journal_title：AAPS PharmSciTech

authors： Shivkumar G,Kazarin PS,Strongrich AD,Alexeenko AA

更新日期：2019-10-31 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:Combined dissolution and permeation systems are designed to simultaneously assess the dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs therefrom. However, there were still some limitations on predicting the possible absorption rate-limiting steps and improving the in vitro-in vivo corr...

journal_title：AAPS PharmSciTech

authors： Li Z,He X,Tian S,Feng G,Huang C,Xun M,Wu Z,Wang Y

更新日期：2019-10-24 00:00:00

abstract：:Anti-vascular endothelial growth factor agents have been widely used to treat several eye diseases including age-related macular degeneration (AMD). An approach to maximize the local concentration of drug at the target site and minimize systemic exposure is to be sought. Sunitinib malate, a multiple receptor tyrosine ...

journal_title：AAPS PharmSciTech

authors： Bhatt P,Narvekar P,Lalani R,Chougule MB,Pathak Y,Sutariya V

更新日期：2019-08-09 00:00:00

abstract：:Transcutaneous immunization using a microneedle device presents a promising alternative to syringe-based injection of vaccines. The aim of this study was to investigate the effective immune response elicited after application of tetanus toxoid antigen-loaded dissolvable microneedles (TT-MN) in mice model. Dissolvable ...

journal_title：AAPS PharmSciTech

authors： Pattarabhiran SP,Saju A,Sonawane KR,Manimaran R,Bhatnagar S,Roy G,Kulkarni RB,Venuganti VVK

更新日期：2019-07-22 00:00:00

abstract：:The main principles of green chemistry and engineering were extended to pharmaceutical formulations to prepare eco-friendly surfactant-free dry emulsion tablets (SFDETs) devoid of solvents or synthetic surfactants. Surfactant-free emulsions were stabilized by in situ cyclodextrins/sweet almond oil inclusion complexes ...

journal_title：AAPS PharmSciTech

authors： Badr-Eldin SM,Labib GS,Aburahma MH

更新日期：2019-07-18 00:00:00

abstract：:The utilization of ferrets as a non-clinical model for disease is rapidly increasing within drug development. Many of these models include respiratory diseases that involve targeted drug delivery via nose-only inhalation. While the deposition patterns within other non-clinical models (mice, rats, canines, and non-huma...

journal_title：AAPS PharmSciTech

authors： Kuehl PJ,Chand R,McDonald JD,Hava DL,DeHaan WH

更新日期：2019-07-01 00:00:00

abstract：:Particulate drug delivery systems (PDDS) have been broadly explored as platforms for delivery of drugs, enzymes, cells, and vaccines for pharmaceutical applications. Studies suggest that microspheres (MS) can stimulate innate immune cells even without a drug payload; however, less is known regarding how they impact ho...

journal_title：AAPS PharmSciTech

authors： Vaghasiya K,Eram A,Sharma A,Ray E,Adlakha S,Verma RK

更新日期：2019-06-27 00:00:00

abstract：:Polymeric films are safe and effective and can be used for vaginal administration of microbicide drug candidates. Dapivirine (DPV), an investigational and clinically advanced antiretroviral drug, was selected as a model compound for this study. We have previously developed and clinically tested a quick-dissolving DPV ...

journal_title：AAPS PharmSciTech

authors： Regev G,Patel SK,Moncla BJ,Twist J,Devlin B,Rohan LC

更新日期：2019-06-26 00:00:00

abstract：:Atropine sulfate (AS) fast-disintegrating sublingual tablets (FDSTs) were tested for AS sublingual permeation's feasibility as a potential alternative dosage form to treat organophosphates (OP) toxicity. More than 12,000 OP pesticide toxicity cases were reported in the USA from 2011 to 2014. AS is the recommended anti...

journal_title：AAPS PharmSciTech

authors： Aodah A,Rawas-Qalaji M,Bafail R,Rawas-Qalaji M

更新日期：2019-06-21 00:00:00

abstract：:In order to obtain sustained release of biodegradable microspheres, the purpose of this study was to design and characterize an injectable octreotide microsphere-gel composite system. The octreotide microspheres were prepared by phase separation method, which used PLGA as a carrier material, dimethyl silicone oil as a...

journal_title：AAPS PharmSciTech

authors： Wang T,Zhang C,Zhong W,Yang X,Wang A,Liang R

更新日期：2019-06-21 00:00:00

abstract：:The aim of the present study was to develop a spilanthol emulsion and investigate the effect of oil and drug physicochemical properties on drug release and skin retention at molecular level. Formulation factors including oil, emulsifier, and humectant were investigated by in vitro skin retention/permeation study and t...

journal_title：AAPS PharmSciTech

authors： Yang D,Li W,Fang L,Liu C

更新日期：2019-06-20 00:00:00

abstract：:The aim of the work is to develop a data fusion model using near-infrared (NIR) and process parameters for the predictions of drug dissolution from controlled release multiparticulate beads. Using a design of experiments, ciprofloxacin-coated beads were manufactured and critical process parameters such as air volume, ...

journal_title：AAPS PharmSciTech

authors： Ibrahim A,Kothari BH,Fahmy R,Hoag SW

更新日期：2019-06-18 00:00:00

abstract：:Individualized medicines for pediatrics are a useful alternative if there is no correct dosage marketed for this segment (easy to swallow, adequate volume and content, correct composition for pediatrics, good organoleptic properties, etc.). Its validation process must ensure quality testing: its content uniformity, ph...

journal_title：AAPS PharmSciTech

authors： Suárez-González J,Santoveña-Estévez A,Armijo-Ruíz S,Castillo A,Fariña JB

更新日期：2019-06-03 00:00:00

abstract：:Hard capsules are made from gelatin, an organic polymer obtained through the hydrolysis of collagen present in animal tissues. Gelatin can be degraded by microorganisms and some strategies can be used to control contaminating micro-organisms. Gamma irradiation is considered as an effective sterilization method; howeve...

journal_title：AAPS PharmSciTech

authors： Rodrigues JT,Neto FNS,Ferreira MF,Naves PLF,Guilherme LR

更新日期：2019-05-20 00:00:00

abstract：:A feasibility evaluation of the addition of fumed silica (SiO2) into an agitated dryer to aid spray-dried solid dispersion intermediate (SDSDi) flow during secondary drying and discharge is described. The quantity of SiO2 to enhance the flow character of SDSDi was assessed by measuring particle size distribution, bulk...

journal_title：AAPS PharmSciTech

authors： Lee YC,McNevin M,Ikeda C,Chouzouri G,Moser J,Harris D,Howell L

更新日期：2019-05-03 00:00:00

abstract：:Chemical penetration enhancers are widely used in transdermal drug delivery system. However, few studies have focused on changes of concentration in chemical penetration enhancers. In this study, the effect of concentrations of enhancers on drug release and its mechanism were investigated. Zolmitriptan (ZOL) was used ...

journal_title：AAPS PharmSciTech

authors： Ruan J,Wan X,Quan P,Liu C,Fang L

更新日期：2019-04-25 00:00:00

abstract：:The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limone...

journal_title：AAPS PharmSciTech

authors： Zhu Y,Xu W,Zhang J,Liao Y,Firempong CK,Adu-Frimpong M,Deng W,Zhang H,Yu J,Xu X

更新日期：2019-03-26 00:00:00

abstract：:One-third of the population of the USA suffers from metabolic syndrome (MetS). Treatment of patients with MetS regularly includes drugs prescribed simultaneously to treat diabetes and cardiovascular diseases. Therefore, the development of novel multidrug formulations is recommended. However, the main problem with thes...

journal_title：AAPS PharmSciTech

authors： Cruz-Angeles J,Videa M,Martínez LM

更新日期：2019-03-18 00:00:00

abstract：:Cancerous invasion yields unusual metabolisms providing a significant amount of peptide albuminomes that modulate albumin stability via binding. The study aimed at the investigation of the thermal stability of human plasma albumin with breast cancer of various stages by means of differential scanning calorimetry (DSC)...

journal_title：AAPS PharmSciTech

authors： Faroongsarng D,Sunpaweravong S,Raksawong A

更新日期：2019-03-18 00:00:00

abstract：:The airways are verified as a relevant route to improve antibody therapeutic index with superior lung concentration but limited passage into systemic blood stream. The current research aimed to process spray-dried (SD) powder of Infliximab to assess the feasibility of respiratory delivery of antibody for local suppres...

journal_title：AAPS PharmSciTech

authors： Faghihi H,Najafabadi AR,Daman Z,Ghasemian E,Montazeri H,Vatanara A

更新日期：2019-02-26 00:00:00

abstract：:The second author's name was incorrectly published as "Niha F. Younes". The correct name is "Nihal Farid Younes" as shown above in the list of authors. ...

journal_title：AAPS PharmSciTech

authors： El Assasy AEI,Younes NF,Makhlouf AIA

更新日期：2019-02-25 00:00:00

abstract：:The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment o...

journal_title：AAPS PharmSciTech

authors： Czech T,Lalani R,Oyewumi MO

更新日期：2019-02-15 00:00:00

abstract：:Our aim was to investigate the cellular uptake, in vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier loaded with curcumin (G-NLC). The formulation was prepared by melt emulsification technique, in which water was added to the melted lipids and homogenized to give a uniform sus...

journal_title：AAPS PharmSciTech

authors： Vijayakumar A,Baskaran R,Baek JH,Sundaramoorthy P,Yoo BK

更新日期：2019-01-23 00:00:00

abstract：:The potential value of succinylated soy protein (SPS) as a wall material for the encapsulation of ibuprofen (IBU), a model hydrophobic drug, by spray-drying was investigated. A succinylation rate of 93% was obtained for soy protein isolate, with a molar ratio of 1/1.5 (NH2/succinic anhydride). The solubility profile a...

journal_title：AAPS PharmSciTech

authors： Anaya Castro MA,Alric I,Brouillet F,Peydecastaing J,Fullana SG,Durrieu V

更新日期：2019-01-11 00:00:00

abstract：:Topical administration is a preferable choice for local anesthetic delivery. Microemulsions have shown great effectiveness for transdermal transport of lidocaine. However, fabrication of microemulsions containing highly concentrated lidocaine (10%) to provide an extended local anesthetic effect is still a challenge. T...

journal_title：AAPS PharmSciTech

authors： Wang Y,Wang X,Wang X,Song Y,Wang X,Hao J

更新日期：2019-01-09 00:00:00

abstract：:The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 × 2.5 mm tablets with 15% and 90% infill levels. The prep...

journal_title：AAPS PharmSciTech

authors： Öblom H,Zhang J,Pimparade M,Speer I,Preis M,Repka M,Sandler N

更新日期：2019-01-07 00:00:00

abstract：:Direct pulmonary delivery is a promising step in developing effective gene therapies for respiratory disease. Gene therapies can be used to treat the root cause of diseases, rather than just the symptoms. However, developing effective therapies that do not cause toxicity and that successfully reach the target site at ...

journal_title：AAPS PharmSciTech

authors： Terry TL,Givens BE,Rodgers VGJ,Salem AK

更新日期：2019-01-02 00:00:00

abstract：:In this study, the resveratrol spray-dried emulsions were developed using a quality-by-design approach. Further, the product and process factors that affected the quality of the spray-dried emulsions were analyzed and illustrated using an Ishikawa diagram. The product and process risks were prioritized using a risk-ra...

journal_title：AAPS PharmSciTech

authors： Benjasirimongkol P,Piriyaprasarth S,Moribe K,Sriamornsak P

更新日期：2018-12-18 00:00:00

abstract：:Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmona...

journal_title：AAPS PharmSciTech

authors： Chen J,Tang Y,Liu Y,Dou Y

更新日期：2018-11-01 00:00:00

abstract：:In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced ...

journal_title：AAPS PharmSciTech

authors： Rachid O,Simons KJ,Rawas-Qalaji M

更新日期：2018-11-01 00:00:00

abstract：:The impact of pharmaceutical materials properties on drug product quality and manufacturability is well recognised by the industry. An ongoing effort across industry and academia, the Manufacturing Classification System consortium, aims to gather the existing body of knowledge in a common framework to provide guidance...

journal_title：AAPS PharmSciTech

authors： Ferreira AP,Gamble JF,Leane MM,Park H,Olusanmi D,Tobyn M

更新日期：2018-11-01 00:00:00

abstract：:Curcumin chewing gums could be therapeutically beneficial if used by the head and neck cancer patients. High curcumin loading in chewing gums however is needed to achieve desired therapeutic effect. Preparing gums with high drug load is nonetheless challenging because of the negative impact of solids on their masticat...

journal_title：AAPS PharmSciTech

authors： Al Hagbani T,Altomare C,Kamal MM,Nazzal S

更新日期：2018-11-01 00:00:00

abstract：:A folic acid-conjugated paclitaxel (PTX)-doxorubicin (DOX)-loaded nanostructured lipid carrier(s) (FA-PTX-DOX NLCs) were prepared by using emulsion-evaporation method and extensively characterized for particle size, polydispersity index, zeta potential, and % entrapment efficiency which were found to be 196 ± 2.5 nm, ...

journal_title：AAPS PharmSciTech

authors： Raikwar S,Vyas S,Sharma R,Mody N,Dubey S,Vyas SP

更新日期：2018-11-01 00:00:00

abstract：:High inter- and intra-individual variability in the pH of fluids in the human gastrointestinal (GI) tract has been described in the literature. The aim of this study was to assess the influence of physiological variability in fasted pH profiles of media along the GI tract on diclofenac sodium (DF-Na) dissolution from ...

journal_title：AAPS PharmSciTech

authors： Felicijan T,Pišlar M,Vene K,Bogataj M

更新日期：2018-10-01 00:00:00

abstract：:The purpose of the study was to synthesize and characterize a new form of topical membranes as chitosan-based hydrogel membranes for bacterial skin infections. The polymeric membranes were synthesized by modification in free radical solution polymerization technique. High molecular weight (HMW) chitosan polymer was cr...

journal_title：AAPS PharmSciTech

authors： Ahmad S,Minhas MU,Ahmad M,Sohail M,Abdullah O,Badshah SF

更新日期：2018-10-01 00:00:00

abstract：:The recommended method for the biopharmaceutical evaluation of drug solubility is the shake flask; however, there are discrepancies reported about the solubility of certain compounds measured with this method, one of them is candesartan cilexetil. The present work aimed to elucidate the solubility of candesartan cilex...

journal_title：AAPS PharmSciTech

authors： de Campos DP,Silva-Barcellos NM,Lima RR,Savedra RML,Siqueira MF,Yoshida MI,da Nova Mussel W,de Souza J

更新日期：2018-10-01 00:00:00

abstract：:Chemical penetration enhancers (CPEs) are frequently incorporated into transdermal delivery systems (TDSs) to improve drug delivery and to reduce the required drug load in formulations. However, the minimum detectable effect of formulation changes to CPE-containing TDSs using in vitro permeation tests (IVPT), a widely...

journal_title：AAPS PharmSciTech

authors： Shin SH,Srivilai J,Ibrahim SA,Strasinger C,Hammell DC,Hassan HE,Stinchcomb AL

更新日期：2018-10-01 00:00:00